Serum albumin, creatinine and urinary protein creatinine index in patients of tuberculosis : A cross - sectional study

Serum albumin, creatinine and urine protein-creatinine index in tuberculosis patients.

Abstract

ABSTRACT
Background: Tuberculosis one of the most important infectious disease throughout the world. India is a highly populated country and a significant amount of mortality and morbidity is caused by tuberculosis, especially pulmonary tuberculosis.Aim: To evaluate serum albumin, creatinine and urinary protein-creatinine index in patients of tuberculosis.Objectives: To estimate the levels of serum albumin, creatinine, urinary protein and creatinine in patients of tuberculosis (TB) and compare them with that of apparently healthy subjects.Materials and methods: This was a cross-sectional study. A total of 168 subjects were included in this study. Among them, 84 were smear positive PTB patients denoted as case group and 84 were apparently healthy individuals denoted as control group. Biochemical tests were carried out in the Department of Biochemistry, Rohilkhand medical college & hospital. All the statistical analysis were performed by SPSS version 23.0. Results were evaluated by using unpaired student’s t-test and pearson correlation. A p value <0.05 were considered to be statistically significant. Results: The study revealed that mean values of serum albumin were 3.55 ± 0.89 gm/dl and 3.27 ± 0.83 gm/dl in case and control group respectively, and the difference between two groups was not significant (p value >0.001). The mean serum creatinine level was higher in case group when compared to control group. The mean values of serum creatinine were 1.93 ± 1.60 mg/dl and 1.01 ± 0.86 mg/dl in case and control group respectively, and the difference between two groups was highly significant (p value <0.001). The mean value of urinary protein-creatinine index was 0.663 ± 0.982 and 0.147 ± 0.110 in case and control group respectively. The analysis showed that the difference in mean UPCI levels between two groups highly significant (p value <0.001).Conclusion: The protein : creatinine index in random urine is a convenient, quick and reliable method of estimation of proteinuria for diagnosis and monitoring of renal disease in tuberculosis patients.Keywords: Tuberculosis, serum albumin, serum creatinine, UPCI.